Take control in Critical Care
Whether as a result of infection or of a sterile trigger such as severe injury or major surgery, systemic hyperinflammation with increased levels of cytokines can cause significant hemodynamic instability and other organ dysfunction.
Reversing shock – restoring balance
Excessive cytokine release during systemic hyperinflammation can lead to vasoplegia and circulatory shock, posing acute and life-threatening consequences for patients. CytoSorb can help.
Stabilize hemodynamics
CytoSorb, with its unique adsorptive bead technology, has been demonstrated to effectively achieve reversal of vasoplegic shock, e.g. in sepsis.
In intensive care units (ICU), systemic hyperinflammation as in sepsis is the most common cause of death, particularly when it progresses to refractory vasoplegic shock, where the mortality rate increases significantly despite improvements in the standard of care.
Vasoplegic or distributive shock caused by non-infectious triggers can look like septic shock and be just as dangerous with high morbidity and mortality.
Best practice therapy management
Support your decision with CytoScore
This dynamic scoring system is intended to provide support in the decision to initiate CytoSorb Therapy in refractory septic/vasoplegic shock. The score can be calculated 6 hours after initiation of standard therapy for shock. For this purpose, various categories that are meaningful for the hemodynamic condition of the patient are rated with 0, 1 or 2 points in order to arrive at a total score. If the total score is >6 clinical data suggests that initiation CytoSorb Therapy within the next 6 hours might lead to positive outcome effects.
Kogelmann et al., J Clin Med 2021; 10: 2939
Postoperative hyperinflammation management
Major surgeries can trigger temporary systemic hyperinflammation. CytoSorb can help maintain the inflammatory balance crucial for patient stability.
Control postoperative hyperinflammation
Help control post-surgical hyperinflammation and multi-organ dysfunction. When undergoing major surgical procedures, patients often experience a transient inflammatory response that should be considered physiological.
An uncontrolled systemic inflammatory response, however, can contribute to multi-organ dysfunction, which plays a significant role in postoperative morbidity or mortality.
Best practice therapy management
Support your ECMO patients
Reduce elevated levels of cytokines to promote organ recovery for Extracorporeal Membrane Oxygenation (ECMO) patients.
Applications
With two main applications — Venoarterial (VA) ECMO for cardiac and pulmonary support, and venovenous (VV) ECMO for pulmonary support — ECMO is increasingly used in acute respiratory distress syndrome (ARDS) and cardiogenic shock, but morbidity and mortality rates remain high.
Treatment options to enhance the clinical benefits of ECMO support and prevent complications, such as ongoing hyperinflammation, are currently limited.
Enhanced lung rest: improve VV-ECMO outcomes
Viral or bacterial infections, such as pneumonia, influenza, COVID, and non-infectious insults, such as aspiration, trauma, pancreatitis, smoke, and ventilator-induced lung injury, can lead to acute respiratory distress syndrome (ARDS) and respiratory failure, requiring VV-ECMO intervention.
While VV-ECMO addresses hypoxemia and helps prevent ventilator-induced lung injury (VILI), it does not address the underlying hyperinflammation, which can have serious consequences, including endothelial and epithelial damage, capillary leakage, and loss of surfactant.
CytoSorb helps manage this concomitant hyperinflammation and, when used in combination with VV-ECMO to rest the lungs, can enhance lung rest and promote organ recovery — both crucial to improved survival.
Earlier intervention with CytoSorb and VV-ECMO allows for “Enhanced lung rest” in severe-ARDS patients and was associated with shorter need for ECMO therapy, mechanical ventilation (MV) and ICU stay, compared to patients with late treatment start.
Substantial and statistically significant increase in PaO₂/FiO₂ ratio and concomitant substantial and statistically significant decrease of C-Reactive Protein (CRP), Lactate and norepinephrine (NE) were observed in ARDS patients treated with hemoadsorption.
Best practice therapy management
Enhance VA-ECMO Outcomes
Additional Information
- Kogelmann et al., J Clin Med 2021; 10(13):2939
- Rugg et al., Biomedicines 2020; 8(12):539
- Brouwer et al., Crit Care. 2019; 23(1):317
- Akil et al., Thorac Cardiovasc Surg 2021; 69(3):246-251
- Boss et al., PLoS One 2021; 16(2):e0246299
- Rasch S et al., Artif Org 2022; 46(6):1019-1026
- Traeger et al., Int J Artif Organs 2016; 39(3):141-146
- Leonardis et al., Case Rep Crit Care 2018:1205613
- Bottari et al., Front in Pediatrics 2023; 11:1259384
- Friesecke et al., J Artif Organs 2017; 20(3):242-259
- David et al., J Int Care 2017; 5:12
- Akil et al., J Clinical Med 2022; 11(20):5990
- Hayanga et al., Crit Care 2023; 27(1):243
- Calabrò et al., Artif Organs 2019; 43(2):189-194
- Hawchar et al., J Crit Care 2019; 49;172-178
- Kogelmann et al., J Clin Med 2024; 13(1):294
- Zuccari et al., Blood Purif 2020; 49(1-2):110 -113
- Szigetvary et al., Biomedicines 2023; 11(11):3068
- Piskovatska et al., Healthcare 2023; 11(3):310
- Kogelmann et al., J Int Care Soc 2020; 21(2):183-190
- Song, T et al., Front. Med. 2021; 8:773461
- Hayanga J et al., Crit. Care 2023; 27:243
Voices around the world
Access Healthcare Professionals Area
This area is for Health Care Professionals only and provides reports about clinical experiences gained during the use of CytoSorbents products. The information presented reflects the opinions and procedural techniques of individual physicians and is not intended as medical advice. Physician experience, risks, patient outcomes and results may vary.