Restore balance to prevent damage
*Not available in the US
CytoSorb® leverages the power of the bead for a highly effective extracorporeal blood purification solution that is there the moment you need it.
It removes a broad range of toxins or substances that, when present at excessive levels, can be harmful to the body and are not dialysable. CytoSorb Therapy has been proven to help a patient’s body stabilize macro-hemodynamics, improve tissue perfusion, protect vital organs, and reduce bleeding complications.
Proven safety
Over 200,000 treatments administered over the last ten years
Most extensively peer-reviewed adsorber
Over 1,000 research papers, abstracts, posters, manuscripts, and other publications.
Improved patient outcomes
With demonstrated efficacy across cardiovascular, kidney, liver, and critical care.
CytoSorb’s unique mode of action briefly explained
Healthy balance
Normal body function is focused on maintaining a healthy balance.
However, many factors can cause potentially harmful imbalances:
- Uncontrolled over-production of substances after triggers, e.g. infection
- High release of substances due to significant cellular damage
- Insufficient removal due to organ dysfunctions
- High presence of externally supplied substances
- A combination of causes
CytoSorb® can help restore the balance and prevent damage by removing:
- Cytokines in intensive care and cardiac surgery
- Bilirubin in liver dysfunction
- Myoglobin in rhabdomyolysis
- Antithrombotics during CPB
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Healthy balance
Normal body function is focused on maintaining a healthy balance.
-
However, many factors can cause potentially harmful imbalances:
- Uncontrolled over-production of substances after triggers, e.g. infection
- High release of substances due to significant cellular damage
- Insufficient removal due to organ dysfunctions
- High presence of externally supplied substances
- A combination of causes
-
CytoSorb® can help restore the balance and prevent damage by removing:
- Cytokines in intensive care and cardiac surgery
- Bilirubin in liver dysfunction
- Myoglobin in rhabdomyolysis
- Antithrombotics during CPB
CytoSorb® utilizes the power of the bead
- CytoSorb, tightly packed with porous polymer beads, facilitates substance removal through targeted adsorption to restore balance.
- As blood flows through the cartridge, the beads selectively capture hydrophobic substances in a vast network of pores and channels in every bead, while maintaining biocompatibility to prevent coagulation or complement system activation.
- This concentration-dependent mechanism ensures efficient removal at high concentrations while preserving physiological mediators at lower concentrations to maintain normal bodily functions
Distinctive adsorption criteria for safe and effective rebalancing
Utilization of hydrophobic attraction to surface
Size selection :< approx. 60 kDa
Concentration-dependent removal
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Utilization of hydrophobic attraction to surface
-
Size selection :< approx. 60 kDa
-
Concentration-dependent removal
Use of CytoSorb in therapeutic areas
Optimized for critical moments in various therapeutic areas, CytoSorb ensures both safety and effectiveness when needed most.
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Critical Care
CytoSorb is a unique technology proven to effectively and safely reduce elevated levels of cytokines, inflammatory mediators, many bacterial toxins, and substances such as bilirubin and myoglobin. The goal of therapy is to protect vital organs and reduce the severity of organ damage.
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Cardiovascular Care
Use of CytoSorb Therapy can help speed up hemodynamic stabilization and reduce the need for organ support therapies. This technology has demonstrated benefits for cardiovascular patients with, or at high risk of, hyperinflammation or at risk of bleeding due to ticagrelor or rivaroxaban.
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Liver Care
CytoSorb is one of the easiest-to-use and most capable extracorporeal liver support therapies. Unlike dialysis-based therapies, CytoSorb Therapy effectively and simultaneously removes both cytokines and liver toxins – helping to reduce inflammation, unburden the liver to promote liver recovery, and in fulminant cases – bridge to transplant.
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Kidney Care
CytoSorb is a unique technology proven to effectively, safely, and simultaneously reduce elevated levels of cytokines and myoglobin, thereby supporting the restoration of renal function. Hemoadsorption goes beyond renal replacement therapies and significantly reduces inflammatory mediators and metabolites.
Additional Information
- Jansen et al., Crit Care 2023; 27(1):117
- Diab et al., Circ 2022; 145(13):959-968
- Scharf et al., Sci Rep 2021; 11(1);10190
- Albrecht et al., Blood Purif 2024; 53(2):88-95
- Hassan et al., JTCVS Open 2023; 15:190-196
- Chen J et al, Regenerative Biomaterials 2017; 4(1):31-37
- Waalders et al., Crit Care Med 2024; 52(4):e152-e153
- Bernardi et al., Crit Care 2016; 20(1):96
- Poli et al., Crit Care 2019; 23:108
- Gleason et al., Sem Thorac Cardiovasc Surg 2019; 31(4):783-793
- David et al., J Int Care 2017; 5:12
- Kogelmann et al., J Clin Med 2024; 13(1):294
- Soltesz et al., J Clin Med 2022; 11(12):6517
- Rugg C et al., Biomedicines 2020; 8(12):539
- Szigetvary et al., Biomed 2023; 11811):3068
- Riva et al., J Artif Orgs 2023; epub
- Grafe et al., Ren Fail 2023; 45(2):2259231
- Hassan et al., Ann Thor Cardiovasc Surg 2022; 28(3):186-192
- Hassan et al., Ann Thorac Surg 2019; 108(1):45-51
