Executive Management
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Phillip P. Chan, MD, PhD
Chief Executive OfficerDr. Phillip Chan is the Chief Executive Officer of CytoSorbents Corporation (NASDAQ: CTSO). Over the past 16 years, Dr. Chan has led the company through the EU approval and commercialization of its flagship product, CytoSorb, as a novel blood purification therapy to treat cytokine storm and control potentially deadly inflammation seen in life-threatening illnesses in the intensive care unit and cardiac surgery.
Prior to joining CytoSorbents, Dr. Chan led healthcare and life science investments as Partner for the $80M NJTC Venture Fund, one of the largest seed and Series A early-stage venture investors in the greater New York region, and a top 1% performing fund for its vintage.
Dr. Chan is also a co-founder and Vice Chairman of Medality Medical, formerly known as Andrew Technologies, a privately-held medical device company pursuing a surgical cure of Type 2 diabetes through removal of deep mesenteric metabolic fat with its FDA-approved lipoplasty system HydraSolve™.
Dr. Chan received board certification in internal medicine, having completed his residency at Harvard Medical School at the Beth Israel Deaconess Medical Center. He received his MD/PhD from Yale University School of Medicine and his BSc in cell and molecular biology from Cornell University.
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Efthymios N. Deliargyris, MD, FACC, FESC, FSCAI
Chief Medical OfficerDr. Deliargyris is triple board-certified in internal medicine, cardiology, and interventional cardiology with vast clinical experience in treating patients with acute cardiovascular disease having performed thousands of interventional procedures. Prior to joining CytoSorbents in 2020, Dr. Deliargyris was CMO for PLX Pharma (NASDAQ: PLXP) and led the FDA approval of Vazalore, a novel aspirin formulation designed to limit gastrointestinal toxicity.
Before that Dr. Deliargyris was Vice President and Global Medical Lead at The Medicines Company (NASDAQ: MDCO) where he led the FDA and EMA approval of Cangrelor, an injectable potent antiplatelet agent. Before joining industry, Dr. Deliargyris served as Director of Cardiology and Interventional Cardiology at Athens Medical Center and as Assistant Professor of Cardiology and Director of the Intravascular Ultrasound Laboratory at Wake Forest University Medical Center in Winston-Salem, North Carolina.
Dr. Deliargyris’ original research on inflammation and cardiovascular disease and in the optimization of antithrombotic therapies has resulted in over 120 publications in top peer review journals including New England Journal of Medicine, Journal of the American College of Cardiology, Circulation, European Heart Journal and numerous awards, including the prestigious Society of Cardiac Angiography & Interventions (SCAI) Fellowship Award for best research in interventional cardiology in the United States.
He received his Medical Degree from the Kapodistrian University School of Medicine in Athens and completed his residency in internal medicine at Tufts University School of Medicine in Boston where he served as Chief Resident and his fellowship in cardiology and interventional cardiology at the University of North Carolina at Chapel Hill where he also served as Chief Fellow. Dr. Deliargyris is an elected Fellow of the American College of Cardiology (FACC), European Society of Cardiology (FESC) and Society for Cardiac Angiography and Interventions (FSCAI).
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Peter J. Mariani
Chief Financial OfficerMr. Mariani brings over 25 years of experience as a valued partner and strategic financial leader across several high growth medical technology companies. Prior to joining CytoSorbents, Mr. Mariani served as Executive Vice President and CFO of Axogen, Inc., a medical technology company focused on peripheral nerve repair and regeneration, from March 2021 to December 2023, and as its CFO from March 2016 the March 2021.
At Axogen, Mr. Mariani was responsible for all finance and accounting functions, investor relations, information technology and security, and Global Quality. During his tenure, Axogen grew annual revenue from $27 million to nearly $160 million, expanded from one to four nerve repair clinical applications, raised approximately $250 million of capital, executed a comprehensive clinical evidence development and publication strategy, and completed a long-term facility build-out. Prior to Axogen, Mr. Mariani was the Chief Financial Officer of Lensar, Inc., which at the time was privately held and a global leader in next generation femtosecond laser technology for refractive cataract surgery.
Prior to Lensar, he served as Chief Financial Officer at Hansen Medical, Inc., a publicly traded company that designed and manufactured medical robotics for positioning and control of catheter-based technologies. Mr. Mariani’s career also includes 12 years with Guidant Corporation, a global leader in the development and sale of medical devices for the treatment of cardiovascular disease. During his tenure at Guidant, he held senior financial positions of increasing importance, including Vice President of Finance and Administration, Guidant Japan, and Corporate Vice President, Controller and Chief Accounting Officer. He started his career at Ernst and Young, LLP, where he served a diverse client base as a Certified Public Accountant. Mr. Mariani earned a Bachelor of Science in accounting from Indiana University.
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Vincent Capponi, MS
President, Chief Operating OfficerMr. Capponi has more than 20 years of management experience in medical devices, pharmaceuticals and imaging equipment at companies including Upjohn, Sims Deltec and Sabratek. Mr. Capponi joined CytoSorbents Inc. as VP of Operations in 2002, was promoted to Chief Operating Officer in 2005, and then to President in 2020.
Prior to joining CytoSorbents, he held several senior management positions at Sabratek and its diagnostics division GDS. Mr. Capponi was interim president of GDS diagnostics in 2001, and from 2000 to 2001 he was responsible for the integration of the Baxter-Sabratek acquisition. From 1998 to 2000 Mr. Capponi was Senior VP and COO for Sabratek and VP Operations from 1996 to 1998.
Mr. Capponi has extensive experience in process scale-up and high-volume medical disposables production. He received his MSc in Chemistry and his BSc in Chemistry and Microbiology from Bowling Green State University.
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Christian Steiner, MD
Executive Vice President of Sales and MarketingDr. Steiner is a native German and English-speaking sales executive who manages all direct sales and marketing efforts of CytoSorb® in Germany and distributor relationships outside the European Union. Dr. Steiner joined CytoSorbents in 2012 from Critical Care Competence, a critical-care focused outsourced sales and marketing company in Germany, where he was Managing Director.
He previously served as the Director of Corporate Marketing for Pulsion Medical Systems AG, a publicly-traded German medical device company focused on non-invasive hemodynamic monitoring, where he was responsible for launching new products such as PiCCO®, establishing physician relationships, building market awareness, initiating clinical studies, and helping to grow sales to approximately €30 million.
Prior to that, as Director of Global Marketing at Teraklin AG, he led the clinical introduction of MARS™, which at that time was a completely new blood purification technology for liver disease being spun out of University of Rostock, Germany, that was eventually purchased by Gambro AB.
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Christopher Cramer, MMS, MBA
Senior Vice President of Business DevelopmentMr. Cramer joined CytoSorbents in 2013 and currently leads business development at CytoSorbents with more than 15 years of business-development and commercial experience in the medical device field. Prior to CytoSorbents, he was Senior Director of New Venture Development at Johnson & Johnson (J&J). He helped to create and manage J&J’s portfolio of early-stage ventures from inception to product launch, establishing new revenue streams for Johnson & Johnson. He was personally responsible for initiating and driving significant partnership deal flows, and has substantial experience in negotiating and establishing business development relationships across many commercial, non-profit, and government organizations.
These deals encompassed a wide variety of structures, including distribution, promotion, co-development, licensing, merger and acquisitions, and equity investments. Prior to that, he was the Worldwide Strategic Marketing leader responsible for developing and executing branding and business development strategies for J&J’s minimally invasive weight-loss surgery division. Prior to joining J&J, he held multiple leadership positions at PwC Consulting and Parametric Technology Corporation. Chris earned his BSc degree from Miami University, and his MBA and MSc degrees from Carnegie Mellon University.
Voices around the world
Dr. Filipo Aucella
Italy, San GiovanniWhen we started to use CytoSorb®, we were very impressed by the rapid decrease of myoglobin concentrations, and the renal damage also improved very rapidly.
Dr. Maria Grazia Calabro
Italy, MilanCytoSorb is effective in reducing bilirubin, creatinine, and lactate in patients who are critically ill, mainly due to cardiogenic shock.
Dr. Tobias Hübner
Switzerland, MünsterlingenThe reason for us to use CytoSorb in the ICU was the lack of treatment options. We never had anything in sepsis, and CytoSorb® is the new star on the horizon.
Dr. Gabriella Bottari
Italy, RomeWe have applied CytoSorb in critical ill children with septic shock, with very good results.
Dr. Mihai Popescu
Romania, BucharestOur results show a potential benefit of CytoSorb in rebalancing liver function in patients with liver failure compared to MARS.
Dr. Serdar Gunaydin
Turkey, AnkaraOne of the most important indications for us to use CytoSorb® in is cardiac surgery, as it has also been cited in many guidelines.
Dr. Willem Pieter Brouwer
The Netherlands, RotterdamIntervention with CytoSorb may be associated with decreased all-cause mortality at 28 days compared to continuous renal replacement therapy alone.
Prof. Jean Louis Vincent
Belgium, BrusselsI would like to send my congratulations on the 10th anniversary of CytoSorb®. It is great how you have created a new way of blood purification therapy.
Juan Carlos Ruiz-Rodriguez
Spain, BarcelonaThis case highlights that cytokine hemoadsorption can lead to a rapid decrease in IL-10 levels, and significant hemodynamic improvement was achieved.
Dr. Gabriella Bottari
Italy, RomeHemoperfusion with CytoSorb in combination with continuous kidney renal therapy is a valuable therapeutic option in sepsis-associated acute kidney injury.
Dr. Askhat Saparov
Kazakhstan, AstanaCytoSorb was safe and well-tolerated in a pediatric patient and has proven its value as an adjuvant therapy for sepsis in pediatric patient populations.
Prof. Peter Pickkers
The Netherlands, NijmeganThe treatment with the CytoSorb® adsorber does reduce circulating concentrations at day one.
Dr. Abdulrahman Alharthy
Saudi Arabia, RiyadhIn this retrospective case series, CRRT with CytoSorb provided a safe rescue therapy in COVID-19 with associated AKI, ARDS, sepsis, and hyperinflammation.
Dr. Kai Singbartl
USA, PhoenixThe case represents the first successful application of CytoSorb in severe refractory neurotoxicity following treatment with chimeric-antigen-receptor T cells.
Dr. Henriette Roed-Undlien
Norway, OsloIn this in vitro study, apixaban levels were effectively reduced, and the clotting time and thrombin generation assays were normalized by the use of CytoSorb.
Dr. Aleksandr Burov
Russia, MoskowThis case series demonstrates that combined blood purification therapy including CytoSorb may have a role for septic shock patients with primary brain injury.
Prof. JW Awori Hayanga
USA, MorgantownIn COVID-19 ARDS on VV-ECMO + hemoadsorption, 90-day survival 74% and early intervention associated with shorter organ support, supporting “enhanced lung rest”.
Dr. Haider Ghaidan
Sweden, LundCytoSorb restored lung function and reduced PGD in lung transplantation. We suggest this treatment will increase tolerability of donor lungs in recipients.
Dr. Pawel Piwowarczyk
Poland, LublinCytoSorb Therapy was able to facilitate long-term regain of balance between inflammatory process, cytokine production, and bilirubin turnover in the liver.
Dr. Anna Krakowiak
Poland, LodzIn the event of poisoning with inorganic mercury compounds, CRRT using CytoSorb as an extracorporeal blood purification method may be considered.
Dr. Vanja Persic
Slovenia, LjubljanaUse of CytoSorb in shocked SIRS patients was associated with rapid IL-6 decrease and hemodynamic improvement, with improved observed vs predicted survival.
Dr. Simao Rodeia
Portugal, LisbonCytokine adsorption therapy with CytoSorb was employed with no direct complications, and helped control the inflammatory state.
Dr. Christopher Rugg
Austria, InnsbruckCatecholamines decreased within 24 h after initiation of CytoSorb Therapy; in-hospital mortality was significantly lower in the CytoSorb group (35.7% vs 61.9%).
Perfusionist Anna Holmen
Sweden, GothenburgThe accumulated norepi dose in the CytoSorb gp was half or less at all postop time points compared to controls..with significantly lower need for RBC.
Assoc. Prof. Berna Kaya Ugur
Turkey, GaziantepUse of CytoSorb achieved significant decreases in endocan, copeptin, IL-6, procalcitonin and C-reactive protein levels.
Dr. John Ferdinand
UK, CambridgeOur data suggest that adsorption of pro-inflammatory mediators from perfusate with CytoSorb represents potential intervention which may improve organ viability.
Prof. Dana Tomescu
Romania, BucharestThe use of CytoSorb in patients with severe acute pancreatitis was associated with improved hemodynamics and decreased inflammatory markers.
Dr. Arosha Minori Gunasekera
Sri Lanka, ColomboThis patient with acute liver failure was managed successfully with supportive therapy, aided by CytoSorb hemoadsorption and therapeutic plasma exchange.
Dr. Endre Nemeth
Hungary, BudapestIntraoperative hemoadsorption associated with better hemodynamics, lower post-op AKI and RRT, stable bilirubin, and shorter mechanical ventilation time and ICU
Dr. Fatime Hawchar
Hungary, SzegedThe first trial to investigate the effects of early extracorporeal cytokine adsorption treatment in septic shock applied without renal replacement therapy.
Dr. Wun Fung Hui
Hong Kong, Hong KongHemoadsorption with CytoSorb can be considered as an adjunctive therapy for children with severe rhabdomyolysis-associated acute kidney injury.
Dr. Maroua Eid
France, AngersThis case describes the successful use of CytoSorb with CRRT and extracorporeal life support in a combined way to overcome a critical phase of septic shock.
Dr. Marine Peyneau
France, ParisCytoSorb appears to be safe and promising to fight post-lung transplantation inflammation, and should be re-evaluated in a larger study.
Dr. Daniel Lovric
Croatia, ZagrebThis is the first study showing an increase in urinary output and a trend towards better survival among patients on VA ECMO treated with CytoSorb.
Prof. Pedja Kovacevic
Bosnia and Herzegovina, Banja LukaThis case series describes potential positive effects of hemoadsorption in preventing the development of systemic hyperinflammation after vvECMO in ARDS.
Certified Clinical Perfusionist Martin Clerici
Argentina, Buenos AiresIntraoperative use of CytoSorb® in an endocarditis patient with extensive cardiovascular history was associated with improvements in the hemodynamic situation.
Prof. Dorel Sandec
Romania, TimisoaraWe treated more than 75 patients with CytoSorb® because we realized, we feel, we see, we measure a significant effect on the evolution of the patient.
Dr. Voyka Gorjup
Slovenia, LjubljanaThe most prominent clinical effect is the lowering of vasopressors, hemodynamic stability, lowering of interleukins and in those patients who are on vvECMO…
Dr. Candido Amador
Panama, Panama CityIn my experience the vasopressor doses decreased, biomarkers of sepsis (…) and the inflammatory response as well as multiple organ function improved.
Assoc. Prof. Monir Sadat Hakemi
Iran, TehranIt seems that applying the CytoSorb in combination with CRRT in ICU septic patients with AKI is correlated with a significant decrease in mortality.
Dr. Yatin Mehta
India, GurgaonCytoSorb is indicated for use in conditions where elevated levels of cytokine and/or bilirubin and/or myoglobin exist.
Dr. L. Christian Napp
Germany, HannoverIn the most critically ill patients on ECMO support, we observed a drop in catecholamine demand and an improvement in clinical state on ECMO.
Prof. Steffen Mitzner
Germany, RostockWhat strikes you first is that you can stabilize patients in septic shock.