Expanding the dimension of blood purification
CytoSorbents’ technology provides a powerful approach to hemoadsorption. And it all starts with a bead. All our solutions are based on our proprietary biocompatible, highly porous polymer bead technology, which works to effectively, safely, and selectively remove excessive levels of potentially harmful substances.
The incomparable power of bead technology
CytoSorbents’ advanced bead technology – based on beads no larger than grains of salt – is ISO 10993 certified for biocompatibility and hemocompatibility.
Targeted and selective
Only small and middle-sized molecules, up to approximately 60 kDa, can enter the inner porous structure. Size selectivity excludes larger substances such as albumin, coagulation factors, and immunoglobulins from relevant removal, as they cannot enter the beads.
Adsorption of hydrophobic substances
Adsorption is the attachment to a surface, which is based on physical-chemical adhesion, whereas processes like dialysis are based on diffusion or filtration. Only molecules with a hydrophobic structure, such as cytokines and antithrombotic agents, can develop the necessary adsorption interactions to bind and be captured inside the bead.
High biocompatibility
The high bio- and hemocompatibility of the beads prevents hemolysis, undesired coagulation, and complement activation.
Concentration dependent
Substances at high concentrations are removed efficiently by the beads, while the removal of substances at low concentration is much slower. This protects against overtreatment and helps to prevent the removal of naturally-occurring substances at normal levels.
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Targeted and selective
Only small and middle-sized molecules, up to approximately 60 kDa, can enter the inner porous structure. Size selectivity excludes larger substances such as albumin, coagulation factors, and immunoglobulins from relevant removal, as they cannot enter the beads.
-
Adsorption of hydrophobic substances
Adsorption is the attachment to a surface, which is based on physical-chemical adhesion, whereas processes like dialysis are based on diffusion or filtration. Only molecules with a hydrophobic structure, such as cytokines and antithrombotic agents, can develop the necessary adsorption interactions to bind and be captured inside the bead.
-
High biocompatibility
The high bio- and hemocompatibility of the beads prevents hemolysis, undesired coagulation, and complement activation.
-
Concentration dependent
Substances at high concentrations are removed efficiently by the beads, while the removal of substances at low concentration is much slower. This protects against overtreatment and helps to prevent the removal of naturally-occurring substances at normal levels.
What bead technology can do
Our unique bead technology provides physicians with an innovative tool to remove excessive levels of water-insoluble substances and toxins, which are not removed efficiently by other blood purification technologies such as dialysis.
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Cytokine imbalance
Massive, uncontrolled production of cytokines – often called ”cytokine storm” – triggered e.g. by infection (in sepsis) may have acute life-threatening consequences for the patient due to circulatory shock (septic/vasoplegic shock, capillary leakage, and microcirculatory disturbances), which may lead to multiple organ dysfunction and death.
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Removal of excessive cytokine levels
Removal of excessive levels of cytokines helps to restore balance and reduce the harmful effects of cytokine storm and severe inflammation on the body. Clinically, this has many effects such as rapid circulatory stabilization – a prerequisite for recovery of organ function and ultimately patient recovery.
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Bilirubin imbalance
Bilirubin, a breakdown product of hemoglobin, is metabolized and excreted by the liver, and is just one of many substances – such as bile acids – that are often increased in liver dysfunction and failure. Many of these toxins can cause harm to the body, in particular to the liver itself.
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Removal of bilirubin
Rapid removal of bilirubin and other substances should reduce this harmful excess and support liver function.
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Myoglobin imbalance
A major breakdown of skeletal muscle triggered by various factors like e.g. trauma, called rhabdomyolysis, leads to excessive release of the muscle protein myoglobin. This carries the risk of acute kidney injury.
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Reduction of the myoglobin level
Our bead technology enables rapid reduction of the myoglobin level to improve the recovery of renal function.
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Imbalance caused by antithrombotic agents in the context of surgery
Antithrombotic medications are essential in the management of patients with cardiovascular disease. They either block platelet function or a specific coagulation factor. The widespread use of antithrombotic drugs, however, can pose a serious and significant risk of bleeding to patients undergoing urgent surgeries, if there is not enough time for a natural washout of these agents.
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Removal of anti-thrombotic agents
Interoperative use of our bead technology enables rapid removal of those antithrombotic agents to prevent bleeding complications associated with surgical intervention.
Additional Information
- Jansen et al., Crit Care 2023; 27(1):117
- Diab et al., Circ 2022; 145(13):959-968
- Scharf et al., Sci Rep 2021; 11(1);10190
- Albrecht et al., Blood Purif 2024; 53(2):88-95
- Hassan et al., JTCVS Open 2023; 15:190-196
- Chen J et al, Regenerative Biomaterials 2017; 4(1):31-37
- Waalders et al., Crit Care Med 2024; 52(4):e152-e153
- Bernardi et al., Crit Care 2016; 20(1):96
- Poli et al., Crit Care 2019; 23:108
- Gleason et al., Sem Thorac Cardiovasc Surg 2019; 31(4):783-793
- David et al., J Int Care 2017; 5:12
- Kogelmann et al., J Clin Med 2024; 13(1):294
- Soltesz et al., J Clin Med 2022; 11(12):6517
- Rugg C et al., Biomedicines 2020; 8(12):539
- Szigetvary et al., Biomed 2023; 11811):3068
- Riva et al., J Artif Orgs 2023; epub
- Grafe et al., Ren Fail 2023; 45(2):2259231
- Hassan et al., Ann Thor Cardiovasc Surg 2022; 28(3):186-192
- Hassan et al., Ann Thorac Surg 2019; 108(1):45-51
What bead technology can do
Our unique bead technology provides physicians with an innovative tool to remove excessive levels of water-insoluble substances and toxins that are bound to specific proteins and thus not dialysable.
